Fall Research Expo 2024

Antipsychotic And Iron-Reducer Targeting Drug-Induced Psychosis​

My research focuses on discovering effective treatments for the catatonic positive symptoms experienced by patients with schizophrenia. Through a series of meticulously designed trials, combined with keen observation and thorough statistical analysis, I have identified promising directions for potential treatments. This study was conducted in collaboration with fellow researchers in a lab dedicated to schizophrenia research.

The experiments involved six different test cases, where I observed that mice administered Ketamine exhibited significantly more stereotypic behavior compared to those on Saline. As a preventative measure, the use of deferiprone and haloperidol demonstrated a reduction in these behaviors. While the combination of these two drugs did not show clear superiority over haloperidol alone, both interventions effectively decreased the stereotypic circling behavior tracked in the mice.

By performing T-tests, I confirmed the statistical significance of the results, with p-values below the alpha threshold of 0.05. This research advances the understanding of treating schizophrenia, particularly for those suffering from catatonic symptoms, and paves the way for further exploration into therapeutic approaches for this complex condition.

PRESENTED BY
Other
College of Arts & Sciences 2027
Advised By
Dr. Amit Lotan
Senior Psychiatrist; Director, Biological Psychiatry Laboratory
PRESENTED BY
Other
Hadassah-Hebrew University Medical School
College of Arts & Sciences 2027
Advised By
Dr. Amit Lotan
Senior Psychiatrist; Director, Biological Psychiatry Laboratory

Comments