The meniscus protects articular cartilage from load-induced injury in the knee. Damage to the meniscus causes erosion of articular cartilage leading to pain, disability, and possible osteoarthritis. Traditionally, a meniscectomy is performed to remove the damaged portion of the meniscus; however, this procedure leads to increased contact forces between the tibia, femur, and subsequent cartilage. Cadaveric allografts have shown promise but are limited by donor availability, imperfect mechanical matching, and limited repopulation with autologous cells causing a nearly 30% revision rate. To circumvent these shortcomings, we employed an innovative tissue engineering approach to use decellularized allogeneic meniscus in which we have created microchannels repopulated with cartilage progenitor cells (CPCs) obtained from a minimally invasive biopsy from ear cartilage. Cartilage progenitor cells were selected for their high proliferation rate and formation of superior cartilage for meniscus engineering. Our approach leverages the native meniscal blood vessels and elastin fibers to overcome the limitations of previous cartilage decellularization techniques. By selectively removing the elastin fibers and blood vessels uniquely present in the fibro-elastic cartilage of allogeneic meniscus we were able to form microchannels that support effective recellularization and subsequent differentiation. We hypothesize that combining our meniscal decellularized scaffold (MEND) and cartilage progenitor cells will create cartilage with biochemical, mechanical, and phenotypic properties that will integrate into an ex vivo meniscal tear model.