The striatum is the input nucleus of the basal ganglia, a group of subcortical nuclei implicated in decision-making and reward reinforcement. Because of its heavy implication in action-directed behavior, altered function of the striatum has been found to be associated with several psychiatric disorders such as obsessive-compulsive disorder, major depressive disorder, and generalized anxiety disorder. In a mouse model, the function of the striatum is often observed through three main parts: the dorsomedial region of the striatum (DMS), the dorsolateral region (DLS), and the ventral striatum (VS). While the functional differences between the DMS, DLS, and VS have all been well documented, the differences between the anterior and posterior regions of the DMS are less understood. It has been proven that the anterior and posterior regions of the dorsomedial striatum have separate inputs, implying variation in function. In order to better distinguish the differences between the anterior and posterior regions of the dorsomedial striatum, it is possible to manipulate these two regions while the animals perform an operant behavioral task. Furthermore, it is practical to also study the downstream connections of both the aDMS and pDMS to determine whether or not they may also be non-overlapping.