Naproxen sodium and acetaminophen are non-steroidal anti-inflammatory drugs commonly used post dental implant surgery to manage pain. Although most of the dental implant surgeries are performed as atraumatically as possible, post-surgical acute inflammation occurs at the implant site. Pro-inflammatory cytokines such as interleukin-8(IL-8) and interleukin-1beta (IL-1beta) are secreted and can be used as quantitative indicators of postoperative inflammation levels. Previous studies on naproxen sodium had demonstrated its analgesic efficacy, but its effect on local inflammation levels are not well known. The major aim of the study was to compare the local anti-inflammatory effect of naproxen sodium and acetaminophen through quantification of IL-8 and IL-1beta in gingival crevicular fluid (GCF) after implant placement. The second aim was to identify possible demographic traits that have effects on post-surgical local inflammation levels. The double-blinded, randomized study was conducted on 30 adult patients (Mean Age: 44.8 ± 14.2 ), who received one or two dental implants and were treated with either naproxen sodium 440 mg or acetaminophen 1000 mg after implant surgery. GCF was collected using perio papers before and 0, 1, 2, 4, 6, 24, and 72 hours after the implant surgery, and IL-8 and IL-1beta levels were quantified by ELISA.  Levels of both IL-8 and IL-1beta in GCF increased after surgery, peaked at 24 hours, and decreased to near baseline levels by 72 hours.  There was a trend toward lower GCF cytokine levels in patients treated with naproxen sodium compared to those treated with acetaminophen.  Body mass index (BMI) was associated with cytokine levels post-implant.  Patients with BMI>25 kg/m2 had significantly higher levels of IL-8 in GCF compared to patients with BMI<25 kg/m2, regardless of treatment.  A similar relationship was observed for IL-1beta, but was not statistically significant. These results suggest that naproxen sodium may suppress post-implant local inflammatory responses to a greater extent compared to acetaminophen and that BMI is a major factor driving differences in local inflammation after implant placement.  Further studies are necessary to identify the mechanisms underlying these relationships and how they affect clinical outcomes following implant placement