More than 100 million patients acquire skin wounds annually in the United States. Treatment methods to promote scarless wound healing (tissue regeneration) remain elusive and a major unmet clinical need. Open skin wounds are an entry point into the body for pathogens and may lead to infections and serious diseases. Using an established wound healing model on mice (ear hole closure), I showed that a rosemary extract generated in our lab promotes rapid wound healing. I thus seek to understand the mechanism behind this phenotype and discover the compound causing this phenotype in this project.