Quiescent states are a universal feature among animals. However, the molecular basis underlying sleep regulation is not fully understood. The Raizen lab studies mechanisms that regulate sleep behavior using a roundworm, C. Elegans, as a model organism. C. elegans have two types of sleep: developmentally timed sleep, which is similar to human circadian sleep, and sickness-induced sleep. For my research project this summer, I studied the sleep behavior of C. elegans, and in particular sickness-induced sleep, which is relevant to understanding human fatigue during illness. C. elegans sleep, meaning they decrease movement and feeding, after being exposed to stressors like UV radiation, hight heat, and chemicals because it induces cellular stress. During my 10 weeks this summer, I used several methods which focused on finding genes that are required for sickness-induced sleep in C. elegans. The strains of worms I used for the experiments were from the million mutation project (MMP), which is a collection of over 2000 heavily mutagenized worms. The entire collection contains a mutation in almost every gene of the C. elegans genome. Given a few strains of the collection, I was able to perform experiments, such as the WorMotel, genetic crosses, and other assays to find a transcription factor that is required for sickness sleep in C. elegans.