Transplants that are Donor +/Recipient – (D+/R-) for Cytomegalovirus are at highest risk of developing CMV infection, especially in dual-organ transplants, such as simultaneous kidney-pancreas transplants. This is due to the fact that dual-organ transplants require higher levels of immunosuppression, and diseases can take advantage of the weakened immune system. This is especially prevalent in recipients that do not have antibodies for a certain disease, but are receiving organs from donors who have the antibodies. This project examines the effect of CMV in the US context, using detailed chart review and deep phenotyping of cases. By looking at granular outcomes, such as incidence of viremia, graft loss, mortality, and hospitalization data, we were able to gain insight on the impact CMV has on high-risk patients using data analysis.