Parenting practices have the potential to ameliorate children’s risk for engaging in risky behaviors such as substance use. This study looks at the Baumrind model of parenting in relation to substance use, measured by drinking frequency, binge drinking and marijuana use. Authoritative and authoritarian parenting styles differ in terms of closeness, and permissive and authoritative parenting styles differ in terms of autonomy granted to children. Data was drawn from Wave 1 of Add Health, a longitudinal and nationally representative school-based study of students grades 7 through 12. Youth reported on measures of substance use, perceived parental closeness, and the degree to which parents imposed rules or set limits on children’s behaviors. Findings suggest that a lack of close parent-child relationships was associated with substance use in our sample. Additionally, permissive parenting was also associated with greater substance use in our sample. However, we did not find a significant interaction effect between closeness and autonomy for any of our substance use variables.