Optimizing ADRDs Brain Sample Preparation For Ex Vivo MR Image Acquisition
During my time in the Imaging Neurodegeneration Summer Undergraduate Research Experience (IN-SURE) this past summer, I coordinated a joint project between Dr. Dylan Tisdall and Dr. David Irwin. Dr. Tisdall’s research group focuses on optimizing MRI for visualizing Alzheimer’s disease and related dementias (ADRDs) in MRI brain scans. Dr. Irwin’s research group chemically stains post-mortem brain tissue from ADRDs patients to identify their neuropathology (Ex: tau and TDP-43 protein aggregation, neurofibrillary tangles). My role was to develop a novel method for preparing post-mortem brain samples in such a way that optimizes MRI acquisition for Dr. Tisdall, but still allows Dr. Irwin to chemically stain the tissue.