Anorexia nervosa (AN) is an eating and psychiatric disorder that is characterized by significant weight loss, prolonged food refusal, irrational fears of weight gain, and distorted self-images (Weiselberg et al., 2011). The current treatments of AN include behavioral therapy and antidepressants, but a pathology-based treatment does not exist (Muratore et Attia, 2021). Based on existing literature, we hypothesized that restoring peripheral serotonin may rescue the eating habits and bodyweights of ABA animals. In this study, we performed two separate experiments aimed to increase peripheral serotonin and food intake levels of ABA mice. In the first experiment, we injected the ABA mice with Selective Serotonin Reuptake Inhibitors and in the second experiment, we supplied the ABA mice with a tryptophan-enriched diet. We found that the SSRI injection did not increase peripheral serotonin or food intake levels in ABA mice, while the tryptophan-enriched diet increased peripheral serotonin and food intake levels in ABA mice. Our study elucidates the pathology of ABA and reveals a potential path of rescue for hallmark ABA characteristics.