Staphylococcus aureus is a Gram-positive bacteria present in the nose for 30% of adults and 20% on skin. Most common infections are mild skin infections. However, they can become serious or even fatal when they lead to sepsis or osteomyelitis when bacteria spread to the bloodstream.The current diagnostics for severe infections are using blood samples and culturing the bacteria to identify its strain by testing for staph specific structures for identification which takes 24-48 hours. Further understanding of the mechanisms of staph infection and their relationship with red blood cells could lead to improvements in diagnostics with reduced wait time and better accuracy. My project seeked to determine whether staph genomic DNA can bind to red blood cells and the factors affecting the binding. The first experiment was used to determine whether binding of staph DNA occurs and if so at which incubation times. The second and third experiment was used to understand if there was a dose dependent acquisition relationship between the DNA and red blood cell concentration. These experiments demonstrated staph genomic DNA binds very early on to red blood cells. If further research can be done to determine how staph DNA can be recovered from red blood cells, then detection of staph infections from blood samples could provide a quicker and perhaps more accurate diagnosis of staph infections.