Fall Research Expo 2021

Side- effects of nasal steroids use to treat pediatric obstructive sleep apnea syndrome

This summer I worked on research with Dr. Christopher Cielo, focusing on data compilation and secondary analysis of a study investigating the side-effects in obstructive sleep apnea syndrome (OSAS) pediatric patients treated with intranasal corticosteroids (NCS). OSAS is a disorder of breathing during sleep characterized by prolonged partial upper airway obstruction and/or intermittent complete obstruction that disrupts normal ventilation during sleep and normal sleep patterns. Adenotonsillectomy is the primary treatment for childhood OSAS which is expensive and invasive. So, alternative treatments like intranasal corticosteroids are desired. However, the side effects of this treatment need to be studied given exposure to systemic of corticosteroids is directly related to the development of side effects such as adrenal crisis and growth suppression. This study was a randomized double-blind, placebo-controlled trial aimed at determining the effectiveness of using NCS for the treatment of childhood OSAS. The participants were recruited through CHOP and consisted of 134 children aged 5 to 12 with OSAS. Adrenal suppression was analyzed through patient cortisol and ACTH levels. While growth was examined through Dual-energy X-ray scans which is an imaging test that measures bone density. 

PRESENTED BY
PURM - Penn Undergraduate Research Mentoring Program
College of Arts & Sciences 2024
Advised By
Christopher Cielo
Investigator at Sleep Lab at CHOP
Ignacio Tapia
Primary Investigator at Sleep Lab at CHOP
Join Faizah for a virtual discussion
PRESENTED BY
PURM - Penn Undergraduate Research Mentoring Program
College of Arts & Sciences 2024
Advised By
Christopher Cielo
Investigator at Sleep Lab at CHOP
Ignacio Tapia
Primary Investigator at Sleep Lab at CHOP

Comments