Synaptic Transmission Is Delayed During NREM Sleep Compared to Awake State in the Mouse Hippocampal CA1 Commissural Pathway.
The hippocampus is essential for spatial learning and memory, and sleep plays a major role in memory processing. In this study, using in vivo electrophysiological methods, we characterize the latency of hippocampal CA1 field Excitatory Postsynaptic Potentials (fEPSP) response. Then, we compared the latency during Non-rapid eye movement (NREM) sleep and the awake state during the period after fear-conditioning learning. We observed that after learning, the synaptic response during NREM state was delayed by about 0.3 ms compared to awake state. These results suggest that the speed of synaptic transmission is different between the NREM and the awake state. This effect could potentially come from the differences in neurochemical composition of the CA1 region during the NREM and the awake state.
Comments
Were you able to work with…
Were you able to work with the mice in the lab, and if not, what was your experience in working with them? Were you working mostly with the data or the synaptic transmission rate, or other types of recordings?
Interesting poster, Maggie! …
Interesting poster, Maggie! I'm wondering if you can tell me whether the 0.3ms delay between awake and NREM state is in line with what other memory consolidation studies have found. Curious whether 0.3ms is a short-time period, a normal one, or a long one in the studies of synaptic responses!