Fall Research Expo 2021

Does fast-acting antidepressant action of ketamine reverse psychosocial stress-induced hippocampal-dependent cognitive deficits in the mouse?

This summer through the Penn Undergraduate research mentorship program, I worked with Dr. Sanghee Yun in the Eisch lab. This project is titled Does fast-acting antidepressant action of ketamine reverse psychosocial stress-induced hippocampal-dependent cognitive deficits in the mouse?

PRESENTED BY
PURM - Penn Undergraduate Research Mentoring Program
College of Arts & Sciences 2024
CO-PRESENTERS
Raymon  Shi
Raymon Shi - College of Arts & Sciences 2022
Grace Bancroft - College of Arts & Sciences 2023
Jovan Singh Mann
Jovan Singh Mann - College of Arts & Sciences 2024
Advised By
Dr. Sanghee Yun
Assistant Professor Anesthesiology and Critical Care, CHOP; Eisch Lab Assistant Director
Join
  • Harley
  • Raymon
  • Grace
  • Jovan
for a virtual discussion
PRESENTED BY
PURM - Penn Undergraduate Research Mentoring Program
NIH Institutional Training Grant (MH076690, PI: CA Tamminga), NNX15AE09G (PI AJE), MH107945 (PI AJE), a 2018 PENN McCabe Pilot grant, a 2019 IBRO travel grant, and is currently supported by 2019 NARSAD Young Investigator Grant from the Brain and Behavior
College of Arts & Sciences 2024
CO-PRESENTERS
Raymon  Shi
Raymon Shi - College of Arts & Sciences 2022
Grace Bancroft - College of Arts & Sciences 2023
Jovan Singh Mann
Jovan Singh Mann - College of Arts & Sciences 2024
Advised By
Dr. Sanghee Yun
Assistant Professor Anesthesiology and Critical Care, CHOP; Eisch Lab Assistant Director

Comments

This poster and presentation were really fascinating to learn about! It's interesting to hear how fast-acting ketamine reversed cognitive deficits in mice that were exposed to chronic stress to levels similar to that of control mice. I look forward to hearing about the effect fast-acting ketamine has on different behavioral paradigms such as the forced swim test, novelty suppressed feeding test, and open-field test. Translationally speaking, I wonder if there are any side effects to the use of fast-acting ketamine antidepressants in humans. Given the prevalence of MDD, studies on the impact of current medication and novel treatments would be greatly beneficial in treating the disorder. This poster did an amazing job breaking down the effects of psychosocial stress on hippocampal-dependent pattern separation and cognitive flexibility while also providing insight on the impact of fast-acting ketamine in reversing cognitive deficits.