Fall Research Expo 2020

Characterization of Genomic and Phenotypic Variation in the Khoesan Speakers of Southern Africa

I spent the summer working with Dr. Sarah Tishkoff and Dr. Michael McQuillan, characterizing genomic and phenotypic variation in various African populations. Specifically, I focused on the Southern African Khoesan populations. The African continent is home to the most genetic diversity across the planet, and is where all homo sapiens originate from. The Khoesan speakers, known as the San, are hunter-gatherer populations spread across Botswana, Namibia, Angola, Zambia, Zimbabwe, Lesotho, and South Africa. They have the most basal genetic lineages, as  they diverged very early from other human populations. The Khoesan have unique morphological and physiological features, such as the lightest skin tone out of other African populations, a unique hair texture, and are adapted to a hunter-gatherer lifestyle in a desert climate. I looked for genomic signatures of natural selection to identify genetic variants or genes that may have been adaptive in this population.

PRESENTED BY
PURM - Penn Undergraduate Research Mentoring Program
College of Arts & Sciences 2023
Advised By
Join Nicole for a virtual discussion
PRESENTED BY
PURM - Penn Undergraduate Research Mentoring Program
College of Arts & Sciences 2023
Advised By

Comments

Nicole,

Congrats on doing a great job on your project and your presentation!

Best,

Sarah

What an interesting project, Nicole--and great presentation.  I'm curious about what your criteria were for identifying "genes that looked interesting" prior to annotation.  Can you clarify?  On another note, are you familiar with how this genetic material was originally obtained and/or anything about the overall relationship between the research community and the Khoesan speakers (the San)?